Are you a scientist currently studying or have plans to study one of these 5 tryptamine psychedelics?

1. 4-Hydroxy-N,N-Diisopropyltryptamine (4-OH-DiPT)
2. 5-Methoxy-alpha-Methyltryptamine (5-MeO-AMT)
3. 5-Methoxy-N-Methyl-N-Isopropyltryptamine (5-MeO-MiPT)
4. 5-Methoxy-N,N-Diethyltryptamine (5-MeO-DET)
5. N,N-Diisopropyltryptamine (DiPT)

If so, let us know what you’re working on and how these substances being put in Schedule I might impact your work by filling out our story share tool.

The DEA has released a notice of proposed rulemaking which would place these 5 tryptamines into Schedule I of the Controlled Substances Act. 

Placement into Schedule I would substantially harm scientific research conducted with these compounds. Testimony from scientists has repeatedly revealed that obtaining a Schedule I registration from the DEA often takes longer than a year, is burdensome and labor-intensive, and can dissuade researchers from studying these compounds at all.

Some of these compounds are currently showing therapeutic potential in humans. Reunion Neurosciences is currently conducting Phase 2 clinical trials with a prodrug (a drug that converts to a psychoactive form after ingested) of 4-OH-DiPT and has earned FDA Breakthrough Therapy designation for this indication. This designation means that the FDA has recognized the utility of research and development leading to the discovery of this important use. 

Additionally, Mindstate Design Labs is developing a chemical formulation of 5-MeO-MiPT for several neuropsychiatric disorders. Thus, to say that these substances have “No accepted medical use” and “high potential for abuse” is shortsighted and not in line with the best available evidence.

Most importantly, we don’t know what we don’t know! Some or all of these compounds could have therapeutic utility in humans, or are already extremely useful to scientists studying how serotonin and psychedelics work in the brain. If they’re scheduled and criminalized this research becomes much harder to complete and some breakthrough discoveries may never be made. 

SSDP’s Science Policy Committee wants to hear from you! Even if you don’t want to be directly involved with our fight against the DEA, you can still share your story or research with these compounds so we can raise awareness of the importance of keeping research legal. 

So if you are currently studying or have plans to study one of these five compounds, please consider sharing your work with us through our easy-to-use story tool. It takes 5 minutes to make an impact!